Current Members
Dual Native
Chemical Ligation
Theoretical Aspects of Stereoselective Chemical Glycosylation
Glycobiology: Catalytic Mechanism and Inhibition of Peptidoglycan Transglycosylases
Carbohydrates & Glycoconjugates: Essential Biomolecules
Professor Liu Xuewei devotes to the carbohydrate-related fields of research, including the development of methodologies for chemical synthesis of oligosaccharides, synthesis and characterization of various glycoconjugate molecules, glycobiology investigations, and theoretical investigation of glycosylation reactions.
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Xiao-Lin Zhang, Han Ding, Aoxin Guo, Xue-Wel Liu*, “Transglycosylases in Peptidoglycan Biosynthesis: Advances in Structure, Function, and Antimicrobial Development”, SCIENCE CHINA Chemistry, 2025, DOI: 10.1007/s11426-024-2601-y.
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Xianyang Wang, Han Ding, Aoxin Guo, Xiaofei Song, Peng Wang, Ni Song, Biao Yu, Peng Xu,* Xue-Wei Liu,* and Ming Li*, Gold(I)-Catalyzed 2-Deoxy-β-glycosylation via 1,2-Alkyl/Arylthio Migration: Synthesis of Velutinoside A Pentasaccharide”, J. Am. Chem. Soc. 2025, 147, 4469-4481.
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Xiao-Lin Zhang, Gábor Báti, Chenyu Li, Aoxin Guo, Claresta Yeo, Han Ding, Kumar Bhaskar Pal, Yuan Xu, Yuan Qiao, and Xue-Wei Liu. GlcNAc-1,6-anhydro-MurNAc Moiety Affords Unusual Glycosyl Acceptor that Terminates Peptidoglycan Elongation, J. Am. Chem. Soc. 2024, 146, 7400–7407.
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Han Ding, Xiao-Lin Zhang, Ao-Xin Guo, Qian Ping Lee, Chao Cai, Ming Li, Hongzhi Cao, and Xue-Wei Liu. A Strain-Promoted Divergent Chemical Steroidation Unveils Potent Anti-Inflammatory pseudo-Steroidal Glycosides, J. Am. Chem. Soc. 2024. https://doi.org/10.1021/jacs.4c00537.
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Han Ding, Jian Lyu, Xiao-Lin Zhang, Yuan Xu, Yu-Han Zhang, Xue-Wel Liu, Efficient O- and S-glycosylation with ortho-2,2-Dimethoxycarbonylcyclopropylbenzyl Thioglycoside Donors by Catalytic Strain-Release, Chem. Sci. 2024, 15, 3711–3720.
Nanyang Technological University
School of Chemistry, Chemical Engineering and Biotechnology (CCEB)